HomeSpecial CategoriesSurgery & Regenerative MedicineCompression or Surgery: Which is better for treating venous leg ulcers?

Compression or Surgery: Which is better for treating venous leg ulcers?

A new study published in the New England Journal of Medicine provides doctors with scientific evidence to support changing the current clinical guidelines for the treatment of venous leg ulcers.

Leg ulcers are open sores that develop just under the skin, often just above the ankle.  Leg ulcers can be caused by trauma or from conditions such as obesity, diabetes, poor circulation, or immobility due to infirmity or paralysis. Additionally, having had one leg ulcer can increase the risk of having more in the future.

Leg ulcers are very painful. Treatment typically involves cleaning the wound and covering it with a sterile bandage. Patients are instructed to keep the affected leg elevated whenever possible to improve circulation and decrease pressure and swelling.  In many cases, patients are given a compression bandage to wear on the affected leg to further aid blood circulation.  Most ulcers heal within 3-6 months. Presently, ablation surgery to fix venous reflux is often only recommended when a leg ulcer is taking longer than this to heal.

However, using compression bandages to treat leg ulcers does not address the underlying poor circulation and/or varicose veins. A new study published in the New England Journal of Medicine, researchers from London investigated whether immediate surgical treatment of the varicose veins improved healing times and ulcer recurrence rates.

A total of 450 patients with venous leg ulcers were randomly assigned to two treatment groups. One group received compression therapy for their leg ulcers, while the other group received initial compression therapy followed by endovascular ablation to treat their varicose veins within two weeks’ time. The researcher found that the ulcer healing time was significantly shorter (averaging 56 days vs 82 days) when the ulcers were not treated with compression alone. Moreover, patients treated with early ablation were ulcer-free for 306 days as opposed to 278 days for patients in the compression therapy treatment group.

This study provides doctors with scientific evidence to support changing how venous leg ulcers are typically treated since current guidelines specify that surgical ablation be deferred and prescribed only in situations where healing is prolonged. According to the data from this study, waiting may, in fact, only serve to lengthen healing times and result in an increased risk for new ulcer formation.

Written by Debra A. Kellen, PhD


(1) Gohel MS, Heatley F, Liu X, et al. A randomized trial of early endovenous ablation in venous ulceration. N Engl J Med 2018. 10.1056/NEJMoa1801214.
(2) Mayor, S. (2018). Early endovenous ablation achieves faster healing of venous leg ulcers than compression therapy, study finds. BMJ 2018;361:k1805 doi: 10.1136/bmj.k1805 (Published 24 April 2018)

Debra Kellen PhD
Debra Kellen PhD
With undergraduate degrees in Neuroscience and Education from the University of Toronto, Debra began her career as a teacher. Nine years later, when she moved to Michigan, Debra earned a Ph.D. in Education Policy from the University of Michigan. Today, Debra organizes conferences and conducts workshops to provide training and support for educators and medical professionals on effective coaching, staff recruitment and training, and creating a culture of continuous improvement. She loves to read and enjoys the challenge of translating medical research into informative, easy-to-read articles. Debra spends her free time with her family, travelling, wandering through art fairs, and canoeing on the Huron River.


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