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Turmeric Supplement Review

Turmeric is a natural spice that is commonly used in Indian dishes, particularly in curries.

This article reviews the health claims of turmeric supplements.

While turmeric has been used for many years as herbal medicine in Asian countries, more recently, the benefits of turmeric are being uncovered by the scientific community.

Here we review the medical studies using turmeric supplements to treat a variety of conditions.

What is turmeric?

Turmeric is a flowering plant that belongs to the ginger family. This plant is native to India and Southeast Asia. It

is the root of the turmeric plant that is dried and ground into a fine turmeric powder that is then used in cooking.

Turmeric contains an antioxidant – curcumin.

Antioxidants work to protect your body’s cells from the damaging effects of free radicals. Curcumin is also anti-inflammatory, which means that it can also reduce the damage that occurs due to increased inflammation in the body.

What are the claims?

There are many claims regarding the health benefits of turmeric and its active component, curcumin, specifically related to its antioxidant and anti-inflammatory properties.

But what does the science say? Is there any evidence that curcumin is beneficial for health or fighting disease?

This article reviews research using turmeric supplements in clinical trials for a range of medical conditions.

Turmeric (Curcumin) for arthritis

There is evidence that curcumin has anti-arthritic effects in patients with arthritis – both osteoarthritis and rheumatoid arthritis.

Clinical trials that assigned patients to take curcumin supplements reported improvements in pain and physical functioning ability when patients were taking curcumin supplements that also contained piperine.

In some studies, a reduction in indicators of inflammation was also observed in patients taking curcumin supplements.

Similar pain reduction has been noted in patients taking curcumin compared with those taking ibuprofen for arthritis pain.

A systematic review of scientific evidence concluded that taking curcumin supplements for eight to twelve weeks was associated with reduced symptoms of arthritis, reaching effectiveness similar to diclofenac sodium and ibuprofen.

Based on this evidence, the researchers concluded that “turmeric extracts and curcumin can be recommended for alleviating the symptoms of arthritis, especially osteoarthritis”.

Turmeric (curcumin) for metabolic syndrome

Since obesity is associated with chronic inflammation, it would follow that the anti-inflammatory effects of turmeric could also be beneficial for people who are overweight or obese.

Clinical trials have found that patients with metabolic syndrome who took curcumin supplements containing piperine had a reduction in molecules associated with inflammation.

Curcumin supplements have also been found to reduce the amount of bad cholesterol in the blood while increasing levels of good cholesterol. 

Turmeric (curcumin) for mood & memory

The effects of curcumin on mood and cognition were assessed in a randomized double-blind placebo-controlled clinical trial.

This trial reported a significant improvement in participants’ ability to complete attention and memory activities.

The study also reported beneficial effects of curcumin supplements on mood – which included fatigue, contentedness, and calmness. 

Turmeric (curcumin) for anxiety & depression

Participants in a randomized double-blind cross-over trial were given either a curcumin supplement complex or a placebo (no curcumin), followed by a period of no treatment and then a ‘cross-over’ to the alternate treatment group.

In this study, measures of anxiety were significantly reduced after taking curcumin supplements.

However, the study reported no difference in depression scores following treatment.

Another randomized clinical trial reported that curcumin treatment was associated with significant improvements in depressive symptoms in patients with major depressive disorder.

Turmeric (curcumin) for irritable bowel syndrome

Some evidence exists to suggest that curcumin may also be beneficial for patients with irritable bowel syndrome (IBS).

One clinical trial combined curcumin with fennel essential oil – due to its known calming effects on the bowels. The study reported that the combination provided significant relief of symptoms after a period of 30 days.

This included reductions in abdominal pain and improved quality of life.

The study found that after the treatment period, the proportion of patients who were ‘symptom-free’ was significantly greater in the group that were taking the supplements.

Turmeric (curcumin) for allergies

A two-month-long clinical trial that administered curcumin or placebo control to over 200 patients with allergic rhinitis reported on nasal symptoms following treatment.

The study found that curcumin reduced the amount of sneezing and nasal congestion, which was associated with changes to a range of molecules that are involved in the immune response that occurs during allergic reactions.

Although a pilot study, this trial demonstrated the ability of curcumin to improve symptoms associated with allergic rhinitis, resulting in improved airflow through the nasal passages.

Turmeric (curcumin) for weight loss

In addition to the anti-inflammatory effects of curcumin investigated in patients with metabolic syndrome, the effect of curcumin on weight loss in patients with metabolic syndrome has also been investigated.

After taking a curcumin supplement, patients had an increase in weight loss, reduced percent of body fat, and greater reductions to waistline, hip, and BMI measurements compared to patients who did not take curcumin.

Turmeric (curcumin) for endometriosis

Studies have found that curcumin reduces inflammation by blocking signaling of the same inflammatory molecules that play a role in endometriosis.

Other processes known to play a role in endometriosis such as oxidative stress and angiogenesis (the formation of blood vessels) are also prevented by curcumin.

Are there any side effects of taking turmeric (curcumin) supplements?

Curcumin is generally considered to be safe and well tolerated, with a recommended daily intake of 0-3mg per kg of body weight. T

he side effects associated – typically with high doses – of curcumin can include yellow stool, rash, headache, nausea, and diarrhea.

What are the best turmeric (curcumin) supplements?

According to research studies, the best curcumin supplements to take are those that are contained in a complex with a molecule that increases the bioavailability of curcumin – for example, piperine (the bioactive compound found in black pepper).

In this way, the absorption of curcumin is increased in order to maximize the associated health benefits. 

Always speak with your doctor before taking any supplements to make sure that they are right for you.

References

  1. Curcumin: A Review of Its’ Effects on Human Health. Hewlings SJ, Kalman DS. Foods. 2017;6(10):92. Published 2017 Oct 22. doi:10.3390/foods6100092
  2. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Daily JW, Yang M, Park S J Med Food. 2016 Aug; 19(8):717-29.
  3. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen. Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni S. J Pain Res. 2013; 6():201-5.
  4. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Lopresti AL, Drummond PD. J Affect Disord. 2017;207:188-196. doi:10.1016/j.jad.2016.09.047
  5. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Cox KH, Pipingas A, Scholey AB J Psychopharmacol. 2015 May; 29(5):642-51.
  6. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Kocaadam B., Şanlier N. Crit. Rev. Food Sci. Nutr. 2017;57:2889–2895. doi: 10.1080/10408398.2015.1077195.
  7. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M Chin J Integr Med. 2015 May; 21(5):332-8.
  8. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. Portincasa P, Bonfrate L, Scribano ML, et al. J Gastrointestin Liver Dis. 2016;25(2):151-157. doi:10.15403/jgld.2014.1121.252.ccm
  9. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Wu S, Xiao D. Ann Allergy Asthma Immunol. 2016;117(6):697-702.e1. doi:10.1016/j.anai.2016.09.427
  10. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Bertuccioli A. Eur Rev Med Pharmacol Sci. 2015;19(21):4195-4202.
  11. Vallée, A., & Lecarpentier, Y. (2020). Curcumin and Endometriosis. International journal of molecular sciences21(7), 2440. https://doi.org/10.3390/ijms21072440

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