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HomeMedicineInternal MedicineCan nutrients from dietary supplements raise or reduce the risk of disease?

Can nutrients from dietary supplements raise or reduce the risk of disease?

A study of American adults evaluated the link between nutrient intake from dietary supplements and mortality.

In 2015, the market revenue of vitamin supplements was estimated to be worth more than US$50 billion. By 2024, the global dietary supplements market is expected to reach US$278 billion.

Dietary supplements are commonly taken to compensate for a missing nutrient in the diet, prevent a deficiency, or potentially reduce the risk of certain diseases.

As defined by The U.S. Federal Food, Drug, and Cosmetic Act, a dietary ingredient is “a vitamin; mineral; herb or other botanical; amino acid; dietary substance for use by man to supplement the diet by increasing the total dietary intake.” As per the FDA, common dietary supplements consumed include calcium, vitamin D, fish oil, Echinacea, garlic, and green tea.

A study published in the Annals of Internal Medicine aimed to evaluate the link between the use of dietary supplements and mortality from all causes, cancer, and cardiovascular disease. Moreover, they assessed whether or not the intake of nutrients from food versus supplements had any effect on mortality.

Data was collected from individuals participating in the U.S. National Health and Nutrition Examination Survey (NHANES).

Individuals were asked about their use of dietary supplements in the previous 30 days, in addition to the name, frequency, and duration of intake. Nutrient intake from foods was assessed by trained interviewers using 24-hour diet recalls. Mortality outcomes were determined through linkage to the National Death Index using a probabilistic match.

Most health benefits came from food, not supplements

The results indicated that the most commonly used dietary supplements were vitamin D, vitamin C, vitamin E, calcium, magnesium, and zinc. Adequate intake of vitamin K and magnesium was found to be associated with reduced risk for all-cause death, while adequate intake of vitamin A, vitamin K, copper, and zinc was linked to lower mortality from CVD.

It is important to note, however, that these benefits were restricted to intake from food and not supplements.

On the other hand, an excess intake of calcium (1000 mg/d or higher) from supplements was linked to a greater risk of cancer death. Vitamin D supplement use at more than 10 mcg/day was associated with increased risk for all-cause death and cancer among individuals with blood levels of 25-hydroxyvitamin D at 50 nmol/L or higher, but not when blood levels were less than 50 nmol/L.

A major strength of this study is that a nationally representative sample of U.S. adults was included. However, a few limitations are noted, including the fact that the use of dietary supplements was assessed in the previous 30 days which may not reflect habitual use.

Moreover, supplement use is based on self-reports and thus subject to recall bias. Self-reported dietary intake is also not free from measurement error.

Supplement users tend to live healthier lifestyles overall

The researchers noted that compared to non-users, supplement users were more likely to have a healthier lifestyle in terms of a better diet, a healthier weight, more physical activity, and no smoking. This could have further impacted the results.

Moreover, supplement users were found to have greater levels of nutrient intake from foods compared to nonusers, which may have already put them at a reduced risk of nutrient inadequacy and mortality.

This study found that dietary supplements were not linked with mortality benefits. Instead, adequate nutrient intake from foods was associated with lower mortality, whereas excess intake of some nutrients from dietary supplements could potentially be harmful.

Therefore, these results suggest that the use of dietary supplements themselves does not have direct health benefits.


  1. Chen F et al. “AssociationAmongDietarySupplementUse,NutrientIntake, andMortalityAmongU.S.Adults ACohortStudy.” Annals of Internal Medicine. 2019.


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