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Folinic acid supplements may help autistic children communicate better

In October 2016, a study published in Molecular Psychiatry determined whether folinic acid supplements could help children with autism communicate better.

Up to 2% of American children are said to experience symptoms that place them on the autism spectrum. Many of these children have difficulty communicating and interacting with others, especially in social settings.

While the causes of autism are not well understood, some correlations have been shown. For example, there is evidence that women who took folate supplements (a B vitamin) before conception and during pregnancy had a lower risk of having a child with autism spectrum disorder (ASD). Findings such as these have generated new research investigating folate supplementation as a potential treatment for ASD.

Dietary folate must be reduced to folinic acid if it is to be absorbed by the body.  Various genetic mutations can prevent this reduction. However, previous research has found evidence that children diagnosed with ASD were found to have a higher number of folate receptor autoantibodies. As such, children with ASD should respond to folinic acid.  Folinic acid supplementation requires a prescription but it has been shown to be both safe and well-tolerated.

Led by Dr. Richard Frye from the Arkansas Children’s Hospital Research Institute, researchers conducted a 12-week, double-blind, placebo-controlled, clinical trial to test whether folinic acid supplementation improved symptoms of autism. They enrolled a total of 48 children between the ages of 3-14 in the study. Among these participants, 79% were male. The children were diagnosed with ASD and the researchers randomly assigned them to receive either daily doses of folinic acid or a placebo.

The doses of folinic acid were calculated by weight, with a maximum dose of 50 mg per day. Each child underwent comprehensive in-person evaluations at the start of the study and at 12 weeks. The researchers also asked the parents to complete questionnaires at both times. They published their results in Molecular Psychiatry in October 2016 online and February 2018 in print.

They found that the children who had received the folinic acid demonstrated significantly improved daily living and verbal communication skills.  No significant adverse effects were reported.  Furthermore, they found that the folate receptor alpha autoantibody was a blood biomarker that could be used to predict the child’s response to the folinic acid treatment.

These findings are encouraging because, at present, the only approved medication for autism are antipsychotic medications, which have limited effectiveness and may lead to unwanted side effects. Yet, the researchers state that larger, multi-center trials are needed to confirm these preliminary findings and to determine how long treatment with folinic supplementation is needed.

Written by Debra A. Kellen, PhD

Reference: Frye, R. E., Slattery, J., Delhey, L., Furgerson, B., Strickland, T., Tippett, M., … & James, S. J. (2016). Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. Molecular Psychiatry.  DOI: 10.1038/mp.2016.168

Debra Kellen PhD
Debra Kellen PhD
With undergraduate degrees in Neuroscience and Education from the University of Toronto, Debra began her career as a teacher. Nine years later, when she moved to Michigan, Debra earned a Ph.D. in Education Policy from the University of Michigan. Today, Debra organizes conferences and conducts workshops to provide training and support for educators and medical professionals on effective coaching, staff recruitment and training, and creating a culture of continuous improvement. She loves to read and enjoys the challenge of translating medical research into informative, easy-to-read articles. Debra spends her free time with her family, travelling, wandering through art fairs, and canoeing on the Huron River.


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