Autophagy is a cellular process in which the body removes or repairs damaged cells. It is thought that this process helps to slow the aging process. However, autophagy decreases as you get older. Spermidine helps to regulate autophagy, and it may help support anti-aging. We will explore the role of this compound in autophagy. Potential spermidine benefits will also be reviewed. 

What is spermidine?

Spermidine is a compound naturally found in humans, and it is also found in some foods. It is a polyamine compound that helps to support the health of various cells in the body. Spermidine influences many processes, including cell growth and tissue generation. It also possesses some anti-inflammatory and antioxidant properties. This allows for the elimination of reactive oxygen species that can be damaging.

Aging is an irreversible process. It also increases the risk of developing age-related health problems like heart disease. One contributor to this risk is the decrease in spermidine as we age. Studies on the role of spermidine in longevity continue. We will explore some of the research.

The role of spermidine in autophagy

Polyamines like spermidine are present in mammalian cells. They help these cells grow and multiply in various biological processes. Other polyamines include putrescine and spermine. However, spermidine is the most abundant polyamine in humans. Researchers believe spermidine plays a major role in anti-aging.

Although it is inevitable, many factors influence aging. Factors include lifestyle, genetic interventions, medications, and supplements. Researchers believe spermidine can delay aging in a variety of ways. One way is by inducing autophagy. Spermidine can adjust the level of expression of autophagy-related genes. In one study, supplementation with spermidine increased autophagy in worms and flies. In another study with mice, spermidine induced autophagy in the liver, heart, and muscle.

Spermidine supplements

Supplementation with spermidine may help support heart and brain health. There are a variety of supplement options on the market. Some products come from natural sources like wheat germ extract. Other products contain synthetically created spermidine. Those supplements made from wheat germ may contain extra polyamines. These extra compounds can help increase spermidine levels. However, these supplements tend to be more expensive compared to synthetic spermidine supplements.

When choosing the best spermidine supplement, read product labels carefully. Look for products manufactured under good manufacturing practices. It is also a good idea to review the package label. Review the label for inactive ingredients such as fillers, allergens, or additives. Also, select products that align with your dietary restrictions.

Spermidine may be beneficial in some chronic conditions. There is, however, no recommended standard daily dose. The recommended dose will vary based on the manufacturer. You should take the recommended amount written on the supplement package label. It is also best to speak with your provider prior to starting a spermidine supplement. Your doctor may be able to recommend a daily dose based on your needs.

There are no known side effects of spermidine. The use of this product is generally considered safe. 

Spermidine and aging

Spermidine impacts aging by triggering autophagy. Autophagy is important for several biological processes. Triggering autophagy helps with cellular waste removal and promotes optimal cell functioning. As the level of spermidine declines with aging, a reduction in autophagy occurs. This reduction has a negative impact on longevity. 

Spermidine and health conditions

There are longevity studies on spermidine increasing longevity by preventing age-related health conditions. One such condition is coronary artery disease. Atherosclerosis is a major cause of this condition, especially in the elderly population. In a mouse study, spermidine blocked the development of atherosclerosis by decreasing inflammation.

Spermidine may have a positive effect on memory and dementia. Another study found spermidine to be beneficial for older adults with cognitive decline.

Spermidine may also be beneficial in preventing the development of type II diabetes. Risk factors for type II diabetes include aging, obesity, and a family history. One study described how supplementation with spermidine may improve insulin sensitivity. However, we need more studies to assess the true benefits of spermidine in diabetes. 

Clinical trials have also studied spermidine for its role in bone health. Osteoporosis is the most common disease of the bone and causes low bone mass. Supplementation with spermidine may enhance bone strength and prevent bone loss. as shown in one study in mice.

Current research shows promising benefits of spermidine. Future studies will determine if spermidine supplementation can help prevent chronic health problems. 

Practical tips for incorporating spermidine into your diet

You can also increase spermidine levels in your body by eating certain foods. Foods rich in spermidine also contain other polyamines, which may be beneficial.

·         Wheat and whole grains

·         Broccoli and cauliflower

·         Mushrooms

·         Peas

·         Mangos

·         Soybeans and soy

·         Chicken

Eating foods rich in spermidine is another way to increase your spermidine levels. This may be beneficial for individuals who do not want to take a supplement every day.

Supplementation with spermidine may help to prevent the development of age-related diseases. Spermidine is not known to have side effects. Most of the benefits of spermidine are in animal studies. Limited research is available on its benefits in humans. More research will be needed to confirm the benefits of spermidine. Before taking spermidine, speak with your doctor. They will determine if spermidine is right for you. 

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