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What’s the link between sleep and breast cancer risk?

A study investigating the relationship between sleep and breast cancer found that being a morning person reduces the risk of developing breast cancer in women.

Circadian rhythms are our body’s internal clock that influences our waking and sleeping times. Changes in circadian rhythms have been linked to increased chances of developing cancer, metabolic and cardiovascular diseases. In 2007, the WHO’s International Agency for Research on Cancer classified shift work involving circadian disruptions as being possibly carcinogenic in humans. A number of studies have focused on the negative effects of circadian disruptions such as night shift work, light-at-night on breast cancer risk. For instance, PER2, a gene involved in circadian rhythm regulation has been implicated in breast cancer development.

To examine if modifiable sleep habits have a direct effect on breast cancer risk, researchers from the University of Bristol, UK in collaboration with Harvard Medical School and the Broad Institute at Massachusetts, USA carried out a large-scale observational analysis of data from the UK Biobank (180,216 women) and the Breast Cancer Association Consortium (BCAC) (228,951 women) studies. Their findings were published in the British Medical Journal. The modifiable sleep habits analyzed in this study included one’s waking preferences, sleep duration and, insomnia symptoms. They analyzed genetic variants associated with these modifiable sleep traits using a technique called Mendelian randomization. This method is less prone to measurement errors or confounding (unmeasured) factors that conventional analytical approaches may face. It increases reliability in the findings and strengthens the possibility of a causal relationship between the factors being analyzed.

The analyses on data from the UK Biobank showed an inverse association between morning preference and breast cancer, suggesting that morning preference provided a protective effect against developing breast cancer. This finding was strengthened when the researchers included the data from the BACA data. Additionally, they also note an adverse effect of long sleep duration on breast cancer risk. The data for insomnia symptoms did not provide consistent evidence for increased breast cancer risk.

The researchers note that the lack of ethnic diversity amongst the study participants and the reliance on self-reported sleep data could be limitations in this study. Additionally, it is unclear if it is the preference for mornings versus evening, or if it is the actual behavior that is linked to breast cancer risks, and needs further evaluation. Nevertheless, the findings reported in this study have potential implications in improving the health of the general population and reducing the risk of developing breast cancer.

Written by Bhavana Achary, Ph.D

References:

Richmond RC, Anderson EL, Dashti HS, Jones SE, Lane JM, Strand LB, Brumpton B, Rutter MK, Wood AR, Straif K, Relton CL, Munafò M, Frayling TM, Martin RM, Saxena R, Weedon MN, Lawlor DA, Smith GD. Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study. BMJ. 2019 Jun 26;365:l2327

Lin HH, Farkas ME. Altered Circadian Rhythms and Breast Cancer: From the Human to the Molecular Level. Front Endocrinol (Lausanne). 2018;9:219. Published 2018 May 4

Image by 溢 徐 from Pixabay

Bhavana Achary PhD
Bhavana Achary PhD
Bhavana Achary completed her Ph.D in Molecular Biology and Biochemistry at the Pennsylvania State Universisty, USA, studying gene regulation. Pivoting from the bench to the writer's desk, Bhavana hopes to bring the advances in science and health research to a broader audience while maintaining the scientific rigour and knowledge gained over her years in research. She enjoys the opportunity to keep abreast of the latest in medical research while also making it more accessible to a lay audience. Currently based in Singapore, Bhavana enjoys exploring the Southeast Asian region.
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