Wednesday, May 22, 2024
HomeHealth ConditionsDiabetesSitagliptin Medication is Well Tolerated in Patients with Chronic Kidney Disease

Sitagliptin Medication is Well Tolerated in Patients with Chronic Kidney Disease

Sitagliptin, a drug that increased insulin secretion, seems to be safe for diabetic patients with chronic kidney disease.

Glycemia has been commonly improved with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors in patients with chronic kidney disease, and their use is well tolerated. Sitagliptin is a drug pertaining to the class of DPP-4 inhibitors. Its effects are associated with better glycemic control by prolonging the action of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP); however, there is limited information about the long-term safety and tolerability of sitagliptin.

To address this lack of information, researchers evaluated data from 14,528 subjects ≥ 50 years old with type 2 diabetes. The subjects were divided in two groups according to the presence of chronic kidney disease (CKD), where twenty three percent of the participants had CKD. Subsequently, the researchers compared several different outcomes between the groups with CKD and without CKD. The incidence of cardiovascular and adverse events such as malignancy, bone fracture, severe hypoglycemia, and diabetic complications were evaluated. It was found that the incidence of these events was higher in the group of patients with CKD when compared to those individuals without CKD.

Researchers also compared the incidence of diabetic-related complications like diabetic eye disease, neuropathy, and renal failure, among participants receiving sitagliptin and those receiving a placebo. A 3-year follow-up period identified similar incidence rates of diabetic (neuropathy, eye disease, renal failure, and severe hypoglycemia) and other complications (bone fracture, malignancy, and pancreatitis) between subjects who received or did not receive sitagliptin.

Researchers were able to conclude that a treatment based on sitagliptin did not cause significant adverse events and was well tolerated for the subjects with chronic kidney disease.

Written By: Vagner Raso

Add to Flipboard Magazine.

RELATED ARTICLES

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Latest News and Articles

SUBSCRIBE TO OUR NEWSLETTERS

Stay Connected
10,288FansLike
820FollowersFollow
249FollowersFollow
2,787FollowersFollow

Article of the month

Recognizing HIE: A Call for Advocacy

Have you heard of HIE? It’s the second leading cause of infant mortality and lifelong disability worldwide. 2-3 per 1,000 live births in high-income...

Joke Of The Day – May 23

An old man came to the doctor complaining of a very strong pain in his leg. “I am afraid it’s just old age”, replied the...

ADVERTISE WITH US

error: Content is read-only and copy-protected.