reducing calorie intake

Reducing calorie intake in patients with Type 2 Diabetes and severe insulin resistance results in clinically significant reductions in insulin requirements and blood glucose levels.


Type 2 Diabetes continues to be a prevalent and challenging disease and effective treatments are needed. A study done at the Clinical Center of the National Institutes of Health states that a mild caloric restriction resulted in a 44% reduction in insulin doses administered to Type 2 Diabetes and severe insulin resistance patients.

The study looked at 10 patients over the course of a 6-day hospitalization period. The calorie intake consumed by the patients was reduced by 16.5% from 2210 calories per day to 1810 calories per day. The diet consisted of 50% carbohydrates, 30% fat and 20% protein. During their hospital stay, their insulin doses were measured daily and their blood glucose levels were measured each day at 4 points: fasting, lunch, dinner and at bedtime.

The findings of this study show that daily insulin doses decreased by 44% in 9 out of 10 patients following the change in diet, presenting clinically significant results. The blood glucose levels measured at various points during the day also decreased, demonstrating positive results from calorie reduction.

A low caloric diet is an important part of managing Type 2 Diabetes and insulin resistance, yet it tends to be overlooked and rarely emphasized by doctors. The results of this study have only reinforced the importance of diet in Type 2 Diabetes management. Another important point to note is that reducing calorie intake is low cost and available to all patients and therefore can be easily incorporated into people’s lives.




Meehan, CA, Cochran, E, Mattingly, M, Gorden, P, Brown, RJ. “Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin ResistanceMedicine, Vol. 94 no. 30, July 2015.






Written by Mariana Nikolova, BSc.

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