radiation therapy

A study published in JAMA compared the clinical outcomes and adverse effects associated with radical prostatectomy, radiation therapy, and active observation in the treatment of localized prostate cancer.


Prostate cancer is one of the most common malignancies affecting males worldwide. Management of this condition depends on many factors, and a full understanding of the pros and cons associated with various treatment modalities is essential for the patient and clinician to make the best decision.

In a recent study published in the Journal of American Medical Association (JAMA), a group of researchers conducted a prospective cohort study examining the association between different treatment options for localized prostate cancer and patient outcomes. The study included a total of 2250 men, under 80 years of age, who were diagnosed with prostate cancer stage T1-T2 from 2011 to 2012. Participants in the study underwent radical prostatectomy, external beam radiation therapy (EBRT) or active observation. The following outcomes were then measured on 6th, 12th, and 36th month after enrollment in the study: 1) sexual function, 2) urinary incontinence, 3) urinary irritative symptoms, 4) bowel function, 5) hormone levels, 6) health-related quality of life, and 7) survival.

The results of the study show that radical prostatectomy is associated with a greater decrease in the level of sexual function compared to EBRT and observation. While radical prostatectomy greatly improved urinary irritative symptoms compared to the other treatment modalities, it was also associated with more episodes of urinary leakage or incontinence. There were no significant differences found on other outcomes measured.

Overall, the findings of this study provided a good overview on the different clinical outcomes associated with the treatment modalities available for localized prostate cancer. This information may help clinicians and patients form the best treatment plan.


Written By: Karla Sevilla

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