Preventing Skin Aging

An ex vivo and a clinical trial were conducted by researchers from France to determine the efficacy of glucosamine sulphate in preventing skin aging.


Glucosamine sulphate is a naturally occurring compound in the body, aiding in the production of different substances such as hyaluronic acid, heparan sulfate, and glycosaminoglycans. Glycosaminoglycans, together with elastin and collagen, are the main components of human skin and help in maintaining the skin’s youthful glow. When a person ages, there is a gradual loss of collagen and elastin which leads to the development of wrinkles. Loss of skin hydration also contributes to this process, which is due to reduction in the levels of hyaluronic acid and heparan sulfate in the body.

A recent study published in Skin Pharmacology and Physiology examined the efficacy of glucosamine sulphate in preventing skin aging. Normal human skin samples were obtained from 3 Caucasian women aged from 32 to 50. Three skin samples from each donor were prepared, with each specimen exposed to different amounts of glucosamine sulphate (0μg/ml, 150μg/ml, 300μg/ml). Different immunohistochemical assays were then done to determine the effects of glucosamine sulphate in preventing skin aging. A clinical trial was also conducted by the researchers. The trial included 8 healthy females aged 50 and above, who had their menopause at least 2 years prior to the study period, and were not taking any hormonal supplements during the duration of the study. The participants were given 1 capsule containing 250mg of glucosamine sulphate daily for 8 weeks. Skin biopsies obtained from the same area were gathered before and after the glucosamine sulphate supplementation, which were then subjected to polymerase chain reaction (PCR).

The results from both methods show that glucosamine sulphate may play a role in preventing skin aging. Immunohistochemical assays revealed that there is direct relationship between levels of glucosamine sulphate and the expression of hyaluronic acid receptors and collagen production. Levels of vimentin, a protein which plays a role in skin repair, as well as collagen I and III, were observed to be increased after 8 weeks of glucosamine sulphate supplementation. However, the study failed to demonstrate the effects of glucosamine sulphate on skin repair and wound healing, which can be further investigated in future studies. Overall, glucosamine sulphate supplementation may provide a promising method of slowing the effects of aging in the skin.


Written By: Karla Sevilla

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