Tuesday, May 21, 2024
HomeWellnessCosmetologyLonger-Lasting Botox Injections Mean Less Trips to the Clinic

Longer-Lasting Botox Injections Mean Less Trips to the Clinic

 

One of the drawbacks of Botulinum Toxin (BTx) is the need for repeated injections. However, studies on a new formulation indicate that it may have longer-lasting effects, requiring fewer injections and trips to the doctor’s office.

 

As we age, our skin loses its elasticity and age-related lines or wrinkles become more visible. The skin also becomes thinner, making soft tissue structures like the facial muscles more visible.To address this, many visit the dermatologist or plastic surgeon for Botulinum Toxin (BTx) injections, one of the most common aesthetic procedures throughout the world. Since the early 2000s, BTx has proven to be an effective means of smoothening out age-related lines in the face and it’s quick, convenient administration in doctor’s offices and clinics has only enhanced its popularity.

BTx is a nerve poison (neurotoxin) that paralyzes muscle by interfering with the nerve cell’s ability to induce muscle contraction. BTx prevents the release of acetylcholine, a neurotransmitter that triggers muscle contraction, causing a loss of muscle tone and smoothening of wrinkle. The main drawback of BTx is that the effects aren’t permanent—the toxin will eventually be cleared by the body, allowing the muscles to regain contractibility. For the patient, this means going back to the clinic for more injections; current doses usually last 3-4 months on the average.

A newer formulation under study may increase the duration of these effects. While the BTx molecule is similarly present, daxibotulinum Toxin A differs from the existing injectables (onabotulinumtoxin A) in that the attaching protein chain (the Daxi) offers greater distribution into the neuro-muscular junction. Greater distribution may potentiate BTx’s paralyzing capacity.

Canadian clinicians and researchers recently concluded a large trial comparing the newer formulation to currently available treatments for glabellar (between the eyebrows) or forehead lines. Over 250 subjects in9 centres across Canada were enrolled in the study and given BTx injections. Both the patient and the clinician were unaware of which formulation was used, and the results were subsequently evaluated for efficacy, safety and duration of action.

The results, published online in the Journal of Dermatologic Surgery, revealed that the clinical outcomes were indeed comparable. The formulations were equally effective at reducing forehead wrinkles or lines. However, the newer BTx formulation had a longer duration of action averaging 24 weeks, 5 weeks longer than the 19 week average of the traditional formulation. These promising results have led to further research and phase three trials that will assess efficacy and safety in larger populations. If approved for use, fewer injections and trips to the clinic will be needed to treat a wrinkly forehead.

Written by Jay Martin, M.D.

Reference:

Carruthers, et al. “Injectable DaxibotulinumtoxinA for the Treatment of Glabellar Lines:  A Phase-2 Randomized Dose-Ranging Multicentre Comparison with OnabotulinumtoxinA and Placebo”. Dermatologic Surgery. 2017. 0:1-11. Doi: 10.10.1097/DDS.00000000000001206.

Add to Flipboard Magazine.

RELATED ARTICLES

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Latest News and Articles

SUBSCRIBE TO OUR NEWSLETTERS

Stay Connected
10,288FansLike
820FollowersFollow
249FollowersFollow
2,787FollowersFollow

Article of the month

Recognizing HIE: A Call for Advocacy

Have you heard of HIE? It’s the second leading cause of infant mortality and lifelong disability worldwide. 2-3 per 1,000 live births in high-income...

Joke Of The Day – May 21

Recently in the news,  it was announced that The New England Medical Journal reports:  9 out of 10 doctors agree that 1 out of...

ADVERTISE WITH US

error: Content is read-only and copy-protected.