Thursday, May 30, 2024
HomeHealth ConditionsCancerCan we improve drugs that reduce chemotherapy side effects?

Can we improve drugs that reduce chemotherapy side effects?

A recent study analyzing the receptor that leads to nausea could be crucial in the development of drugs to reduce chemotherapy side effects.

Most currently used cancer drugs are known to cause many chemotherapy side effects. These unpleasant side effects are sensed through a class of receptors called neurokin 1 receptor (NK1R). Pharmacological targeting of these receptors has been attempted for many decades to reduce chemotherapy side effects (also called chemotherapy-induced nausea and vomiting, CINV). This has led to the development of Aprepitant and Netupitant, drugs that are currently being used to target this receptor and reduce cancer chemotherapy side effects.

The same receptor is also involved in sensing pathological conditions like gastrointestinal disorders, inflammation, migraine, depression, and asthma. Therefore the development of chemical compounds that can target this receptor continues to excite researches in hope of developing additional anti-nausea medications and drugs that can be used to treat diseases influenced by neurokin 1 receptor.

Researchers from the University of Zurich in Switzerland determined the three-dimensional structure of the receptor as it was bound to the drugs Aprepitant or Netupitant. The researchers also isolated receptors when it was bound with a test compound CP-99,994 – a drug identified from a large-scale screening evaluating thousands of chemicals for NK1R inhibitory activity. They published their results in Nature Communications.

The structural analysis revealed that while both the clinically approved drugs (Aprepitant or Netupitant) and the test compound CP-99,994 bind the receptor equally well, only the clinically-approved drugs are retained on the receptor for a longer duration. This improved binding is responsible for the success of Aprepitant or Netupitant in comparison to CP-99,994.

The authors also found a mechanism for this phenomenon. The investigators found that the clinically-approved inhibitors, after binding to the receptor, change its structure in a manner that facilitates the “trapping” of inhibitors onto its surface. In contrast, the test compound can bind the receptor equally well, but it does not induce such a structural change in the receptor and gets released from the receptor.

The author suggested that structural insights like these could accelerate the discovery of anti-nausea drugs that are being developed to manage chemotherapy side effects and treat NK1R influenced pathological conditions.

Written by Vinayak Khattar, Ph.D., M.B.A

Reference: Schöppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schütz, M., Doré, A. S., & Plückthun, A. (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature Communications, 10(1), 17. doi:10.1038/s41467-018-07939-8

Vinayak Khattar PhD MBA
Vinayak Khattar PhD MBA
Vinayak Khattar completed his Master of Biotechnology at D.Y. Patil University in India. He received his Ph.D. in Cancer Biology at the University of Alabama at Birmingham (UAB) and then completed his M.B.A from the UAB Collat School of Business. His research interests lie in identifying mechanisms that dictate protein stability in cancer cells, immuno-oncology, and bone biology. He has seven peer-reviewed publications, over 40 citations, and three awards. He likes to watch Netflix documentaries with his family during his free time.
RELATED ARTICLES

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Latest News and Articles

SUBSCRIBE TO OUR NEWSLETTERS

Stay Connected
10,288FansLike
820FollowersFollow
249FollowersFollow
2,787FollowersFollow

Article of the month

Recognizing HIE: A Call for Advocacy

Have you heard of HIE? It’s the second leading cause of infant mortality and lifelong disability worldwide. 2-3 per 1,000 live births in high-income...

Joke Of The Day – May 30

Patient: Doc, please come to my home as soon as possible! My wife has appendicitis! Doctor: Don't worry. Two years ago I did surgery to...

ADVERTISE WITH US

error: Content is read-only and copy-protected.