Wednesday, June 12, 2024
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Gut hormone may affect response to food and unhealthy eating habits

A recent study investigated how ghrelin, a stomach hormone, promotes individuals’ conditioning to food-related odours and eating behaviors.

Obesity, defined as the excess of body fat, is an increasingly prevalent phenomenon that is associated with an elevated risk of many chronic diseases, including hypertension, diabetes, and cardiovascular disease. Several factors have contributed to the rapid rise in obesity, including the increase in sedentary lifestyles and easy access to unhealthy foods.

Hormone ghrelin promotes eating behaviors

There is a lot of research aimed at identifying and understanding factors that contribute to excessive and unhealthy eating patterns. Notably, the gut hormone ghrelin has been shown to promote eating behaviors and has been associated with dopamine production involved in reward pathways of the brain.

In a recent study led by Dr. Alain Dagher at the Montreal Neurological Institute and Hospital of McGill University in Canada, 38 subjects were given ghrelin and exposed to food or non-food-based odours. At the same time, each participant was exposed to images of random, non-food-related objects. The objective of this was for subjects to associate the specific neutral images with specific food or non-food-related odours. During the study, functional magnetic resonance imaging (fMRI) was conducted to assess brain activity in response to the images.

Ghrelin was associated with higher brain response to images associated with food smells

In summary, the study found that individuals administered with ghrelin exhibited higher activity in brain regions affiliated with the reward response and dopamine. These elevated responses were only exhibited in response to neutral images that were associated with food smells. Moreover, the neutral images associated with food smells were rated as being more pleasant.

Hypersensitivity to food images and smells may contribute to unhealthy eating habits

These findings have significant consequences for obese individuals, as well as those who need to restrict their dietary intakes. Specifically, the study suggests that some individuals may be hypersensitive to food images and smells, which contribute to their unhealthy eating habits. This is particularly important to consider given that we are constantly exposed to food advertisements and smells.

Further research is necessary to better understand the individual factors that may increase responses to food and contribute to excessive and unhealthy eating. Helping educate high-risk individuals on how their body may respond to food-stimuli in the environment will be crucial to ensuring that they can maintain their health.

Written by Haisam Shah, BSc

Reference:  Han, J. E., Frasnelli, J. A., Larcher, K., Boyle, J. A., McConnell, T., Malik, S., … &Dagher, A. (2018). Ghrelin enhances food odour conditioning in healthy humans: an fMRI study. bioRxiv, 311738.


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Haisam Shah BSc
Haisam Shah BSc
Haisam is a first-year Masters student in the Department of Physiology at the University of Toronto. His research involves understanding the role of cardiac fibroblasts in the progressive development of cardiac fibrosis following a myocardial infarction. He graduated from McGill University with a Bachelors of Science – Honors in Pharmacology, where he had the opportunity of investigating potential combination therapies for Glioblastoma Multiforme.


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