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HomeMedicineNeurologyAre brain connectivity changes linked to smoking and drinking?

Are brain connectivity changes linked to smoking and drinking?

Researchers compared brain imaging in smoking and drinking to investigate why people become addicted to nicotine or alcohol.


According to the recent World Health Organization (WHO) statistics, the use of cigarettes and alcohol is widespread, with estimates of over 1.1 billion smokers worldwide and 2.3 billion people who are current drinkers. These high-risk behaviors can lead to serious health problems – around 7 million people die each year from tobacco-related illness.

It is important to understand what underlies the development of these addictive behaviors. Researchers at the University of Warwick investigated whether there are functional brain differences in people who smoke or drink alcohol. They recently published their findings in eLIFE.

The researchers examined data from the Human Connectome Project which involved performing functional magnetic resonance imaging (fMRI) brain scans in the general population. fMRI measures how different parts of the brain are communicating by looking at brain activity when a person is at rest. The pattern of activity shows which parts of the brain are working closely together and which parts are less well connected. The researchers compared the brain connectivity patterns of over 800 people who were smokers or drinkers.

Smokers had low overall brain connectivity and drinkers had high connectivity

Smokers’ fMRIs showed low overall connectivity between brain regions. In particular, they had weaker connections between two brain regions that help people to change or stop a behavior (lateral orbitofrontal cortex and inferior frontal gyrus). This may make it difficult for people to stop smoking. In addition, the nicotine in cigarettes has stimulating effects which may improve communication between different parts of the brain. So smokers may find that smoking helps them to overcome underlying brain communication deficits.

Drinkers’ fMRIs showed high overall brain connectivity. The reward-related systems were especially strongly connected (medial orbitofrontal cortex and the cingulate cortex). Drinkers may be more sensitive to the reward aspects of drinking.

The extent of brain connectivity changes in drinkers and smokers was related to the amount of alcohol and nicotine they consumed. Furthermore, brain changes were detectable even in people smoking only a few cigarettes or drinking one unit of alcohol a day.

The researchers compared the Human Connectome Project fMRIs with those from the IMAGEN brain scanning study to validate their findings. From this comparison, they also noted that the brain changes seen in smokers and drinkers were already present in 14-year-olds who would go on to drink or smoke at age 19. This suggests that functional connectivity differences in the brain may make people more likely to smoke or drink.

Understanding brain changes may help in the prevention of substance addiction

Professor Jianfeng Feng, one of the study’s lead authors, commented, “These are key discoveries that advance our understanding of the neurological basis of smoking and drinking.” He added that these findings may have future implications for prevention and treatment of smoking and drinking addiction behaviors.

Written by Julie McShane, Medical Writer


  1. Cheng W, Rolls, ET, Robbins TW, et al. Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. eLIFE 2019;8:e40765.
  2. Press release, University of Warwick, Jan 8 2019. Different brain areas linked to smoking and drinking. Science Daily
Julie Mcshane MA MB BS
Julie Mcshane MA MB BS
Julie studied medicine at the Universities of Cambridge and London, UK. Whilst in medical practice, she developed an interest in medical writing and moved to a career in medical communications. She worked with companies in London and Hong Kong on a wide variety of medical education projects. Originally from Ireland, Julie is now based in Dublin, where she is a freelance medical writer. She enjoys contributing to the Medical News Bulletin to help provide a source of accurate and clear information about the latest developments in medical research.


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