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Antiretroviral drugs for HIV may increase risky sexual behaviour

A study looked at whether taking antiretroviral drugs for HIV as pre-exposure prophylaxis has resulted in increased risky sexual behavior.

Pre-exposure prophylaxis is a highly effective method in preventing HIV in people who are at substantial risk of HIV infection by taking antiretroviral drugs every day.

It is recommended by the World Health Organization for populations at substantial risk.

However, researchers in Australia recently conducted a study that assessed data from 16,827 gay and bisexual men on pre-exposure prophylaxis. They collected data before and after the roll-out of pre-exposure prophylaxis programs which were funded by the state governments in Victoria and New South Wales.

Their findings were published in the Lancet HIV.

Consistent use of protection lowered with increased use of antiretroviral drugs

The study found that the use of pre-exposure prophylaxis in HIV-negative men increased from 2% in 2013 to 24% in 2017.

However, the men who reported having sex with casual partners and who were taking pre-exposure prophylaxis reported an increase in having sex without condoms from 1% in 2013 to 5% in 2016 and 16% in 2017.

The consistent use of condoms decreased from 46% of men in 2013 to 42% in 2016 and 31% in 2017. The decrease in condom use despite the increase in pre-exposure prophylaxis could undermine the effectiveness of pre-exposure prophylaxis.

In men who were not using pre-exposure prophylaxis and who were HIV-negative or untested, there was an increase of 9% between 2013 and 2017 in this risky sexual behavior of unprotected sex with casual partners was also reported.

The effectiveness of pre-exposure prophylaxis may decrease

The researchers highlighted that the effectiveness of pre-exposure prophylaxis especially at the population level, which has been said to be a game changer for HIV, may decrease in the long term.

They suggested the decline in condom use may be because many men not taking pre-exposure prophylaxis might feel safer because of an increase in other men taking the preventative measure.

Therefore, as they feel safer they may decide to have sex without a condom more often as they think it has become less risky.

The consequences of this increased risky sexual behavior are unknown. However, a decrease in the number of men who have sex with men diagnosed with HIV occurred at the same time as the increase in men taking pre-exposure prophylaxis and a decrease in condom use.

However, the decrease in new HIV diagnoses may be due to an increase in the number of men who know if they have HIV or not by regular testing and the increase in antiretroviral treatments.

A need for more safe sex campaigns with pre-exposure prophylaxis programs

Even though the increase in sexually transmitted diseases (STIs) in gay and bisexual men began before the introduction of pre-exposure prophylaxis in England, recent data from Public Health England has shown that gay and bisexual men are still at a significantly higher risk of being affected by STIs.

Therefore, the recommendation given moving forward is to increase the number of campaigns to promote safe sex with a focus on sexual health in conjunction with the roll-out of pre-exposure prophylaxis programs.

Maximizing the opportunity to increase the conversations surrounding STIs and HIV prevention with the introduction of pre-exposure prophylaxis in gay and bisexual men is essential.

It will not only help ensure individuals have sufficient information in regard to condom use and safe sex but will also help ensure everyone in need has access to services for testing and treatments.

Written by Lacey Hizartzidis, PhD

Reference: Pre-exposure prophylaxis may increase risky behaviour when introduced, study finds. The BMJ. Accessed June 25, 2018.

Lacey Hizartzidis PhD
Lacey Hizartzidis PhD
Lacey has a Ph.D. in Medicinal Chemistry from the University of Newcastle in Australia. Her research investigated the use of flow chemistry to synthesize potential anti-cancer agents. Having authored a number of articles published in international journals, she has developed a love for writing. Coupled with her passion for science and health, Lacey truly enjoys writing for Medical News Bulletin and helping people to understand the important and exciting scientific research being conducted around the world. With an adventurous spirit, Lacey also enjoys travelling the world, living a healthy life and helping others to do so as well.


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